Protective CD8+ T cells induced by malaria sporozoites do not undergo modulation of interleukin-7 receptor expression.

نویسندگان

  • Alexandre Morrot
  • Ian A Cockburn
  • Michael Overstreet
  • Dolores Rodríguez
  • Fidel Zavala
چکیده

CD8+ T cells induced by Plasmodium yoelii sporozoites develop into protective memory cells without undergoing changes in interleukin-7 receptor alpha (IL-7Ralpha) expression, differing from the development of memory CD8+ T cells against viruses, which is associated with enhanced IL-7Ralpha expression. This suggests a microbe-dependent diversity in the signals determining the development of memory populations.

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عنوان ژورنال:
  • Infection and immunity

دوره 74 4  شماره 

صفحات  -

تاریخ انتشار 2006